https://doi.org/10.4081/ijwc.2022.89

Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin

Vol. 6 No. 2 (2022)
Submitted: May 16, 2022
Accepted: June 27, 2022
Published: July 29, 2022
Ulcer, perilesional skin, Rigenase®
Abstract Views: 561
PDF: 129
PDF (Italiano): 322
Appendix (Italiano): 41
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Francesco Petrella
dottpetella@gmail.com
Surgery specialist, ASL Napoli 3 Sud, Italy.
Giuseppe Nebbioso
Surgery specialist, ASL Napoli1 centro, Italy.
Marcello Aquino
Nursing coordinator of the San Giuseppe Moscati Hospital, Avellino, Italy.
Mario Bellisi
Phlebolymphology unit head, Paolo Giaccone Polyclinic University Hospital, Palermo, Italy.
Sara Carella
Specialist in Plastic, Reconstructive and Esthetic Medicine Sapienza University of Rome, Italy.
Rosaria Grace Catalfamo
Vascular surgery specialist Polyclinic University Hospital G. Rodolico - San Marco, Catania, Italy.
Diletta Donateo
Nursing expert, Società Cooperativa Artemisia a R.L., Acquarica del Capo, Italy.
Pasquale Esposito
Surgery Specialist, ASL Napoli 2 Nord, Italy.
Pierluigi Gallo
Vulnologist Sole Responsible MAVI Centre, Naples, Italy.
Maria Grazia Mezzasalma
Nursing and wound care expert, Casale Monferrato, Italy.
Stefano Riccardi
GP and wound care specialist, ASL Roma 6, Italy.
Concetta Romano
Cardiology of vessels specialist, Acireale Hospital, Italy.
Alessandro Scanguzzi
Nursing and wound care expert, Treviso, Italy.

The Triticum Vulgare Extract (TVE) is a particular wheat extract patented by Farmaceutici Damor. TVE (Rigenase®) has been shown to have an important bio stimulation effect promoting the tissue repairing process in vitro. In this context, an observational study was developed to access the effects of a gauze based on Rigenase® and polyhexanide in the treatment of venous ulcers (area <6 cm2 and not beyond the dermal layer) and of damaged perilesional skin whose damage could have also been determined by iatrogenic cause. Inclusion and exclusion criteria were identified and a medication protocol was applied. The study showed that the product based on Rigenase® and polyhexanide is effective in the treatment of venous ulcers and damaged perilesional skin.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Funel N, Dini V, Janowska A, et al. Triticum vulgare extract modulates protein-kinase B and matrix metalloproteinases 9 protein expression in BV-2 cells: Bioactivity on inflammatory pathway associated with molecular mechanism wound healing. Mediators Inflamm 2020;2020:2851949. DOI: https://doi.org/10.1155/2020/2851949
Sanguigno L, Casamassa A, Funel N, et al. Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells. PLoS One 2018;13:e0197493. DOI: https://doi.org/10.1371/journal.pone.0197493
Tito A, Minale M, Riccio S, et al. A Triticum vulgare extract exhibits regenerating activity during the wound healing process. Clin Cosmet Investig Dermatol 2020;13:21-30. DOI: https://doi.org/10.2147/CCID.S216391
D’Agostino A, Pirozzi AVA, Finamore R, et al. Molecular mechanisms at the basis of pharmaceutical grade Triticum vulgare extract efficacy in prompting keratinocytes healing. Molecules 2020;25:431. DOI: https://doi.org/10.3390/molecules25030431
Antonucci I, Fiorentino G, Contursi P, et al. Antioxidant capacity of Rigenase®, a specific aqueous extract of Triticum vulgare. Antioxidants (Basel) 2018;7:67. DOI: https://doi.org/10.3390/antiox7050067
Atkin L, Bućko Z, Conde Montero E, et al. Implementing TIMERS: The race against hard-to-heal wounds. J Wound Care 2019;23:S1-S50. DOI: https://doi.org/10.12968/jowc.2019.28.Sup3a.S1
Stillo F, Ebner H, Lanza G, et al. Linee Guida SICVE/SIF 2016. Ital J Vasc Endovasc Surg 2016;3:1-45.

How to Cite

Petrella, F., Nebbioso, G., Aquino, M., Bellisi, M., Carella, S., Catalfamo, R. G., … Scanguzzi, A. (2022). Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin. Italian Journal of Wound Care, 6(2). https://doi.org/10.4081/ijwc.2022.89
Copyright (c) 2022 The Authors Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

<< < 1 2 3 4 5 

You may also start an advanced similarity search for this article.