https://doi.org/10.4081/ijwc.2020.58
Il miele medicale nella pratica clinica: la nostra esperienza in 75 casi trattati
Ricevuto: 18 febbraio 2020
Accettato: 9 aprile 2020
Pubblicato: 24 luglio 2020
Accettato: 9 aprile 2020
Abstract Views: 1933
PDF: 599
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Autori
Presso la Struttura Organizzativa Dipartimentale (S.O.D.) Clinica di Chirurgia Plastica e Ricostruttiva di Ancona sono stati trattati con miele medicale consecutivamente, nell'arco di 24 mesi, 75 pazienti affetti da lesioni cutanee croniche. Nell'articolo vengono descritti gli ottimi risultati ottenuti in termini di riduzione dei tempi di guarigione delle lesioni trattate, e vengono descritte le caratteristiche chimiche e fisiche del miele medicale che ne spiegano in forma scientifica l'azione.
1. Alvarez-Suarez JM et al. Contribution on honey in nutrition and human health: a review. Mediterranean J of Nutrition and Metabolism, 2010; 3:15-23.
2. Majino G. Man and wound in the ancient world. Cambridge: Harvard University Press, 1975
3. Jones R. Honey and healing through the ages. Honey and Healing. Cardiff: s.n., 2001, p.1-4
4. Nathan C . Antibiotics at the crossroads. Nature, 2004; 431, 899-902.
5. Visweswara RP et al. Honey, propolis and Royal Jelly: a comprehensive review of their biological actions and health benefits. Hindawi ,2017.
6. Kwakmann PHS et al: Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogenes. Eur J Clin Microbiol Infect Dis, 2011;30:251-257.
7. Leher RI et al: Interaction of human defensins with E. coli: mechanism of bacterial activity. J of Clin Investigation,1989;84:553-561.
8. Kwakmann PHS et al: Medical–grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Cl Infectious Diseases, 2008;46:1677-1683.
9. Molan PC et al: The evidence supporting the use of honey as a wound dressing. The intern J of Lower Extremity Wounds, 2005;5:353-356.
10. Simon A et al: Medical honey for wound care-still the "latest resort"?, Evidence-based Complementary and alternative medicine. 2009;6:165-173.
11. Molan PC. Clinical usage of honey as a wound dressing. The intern J of Lower Extremity Wounds, 2004;13:353-356.
12. Molan PC. The antibacterial activity of honey. Bee World, 1992;73:5-28.
13. Aureli P et al. Infant botulism and honey in Europe: a commentary. The pediatric infectious disease J, 2002;21:5-28.
14. Schneider LS et al. Influence of pH on wound healing: a new prospective for wound-therapy? Arch of Dermatol Res, 2007;298:413-420.
15. Adams C et al. Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (leptospermum scoparium) honey. Carbohydrate Res, 2008;343:651-659.
16. Mavric E et al. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptosperum scoparium) honeys from New Zealand. Molecular Nutrition and Food Res, 2008;52:483-489.
17. Fujivara S et al. A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin. The J of Biol Chem, 1990;265:11333-11337.
18. Lensky Y et al. Separate protein body compartments of the worker honeybee (Apis mellifera L.). Comparative Biochemistry and Physiology, 1983;75:607-615.
19. Knecht D et al. Patterns of larvel food-production by hypopharyngeal glands in adult worker honey-bees. Apidologie, 1990;21:457-468.
20. Al-Waili NS et al: Honey and microbial infection: a review supporting the use of honey for microbial control. J of Med food, 2011;14:1079-1096.
21. Majtan J. Methylglyoxal-a potential risk factor of manuka honey in healing of diabetic ulcers. Evid Based Complement Alternat Med, 2011; 2011:295494, Epub 2010 Oct 14.
22. Huang HV et al. Action of antimicrobial peptides: two-state model. Biochemistry, 2000;39:8347-8352.
23. Epand RM et al. Diversity of antimicrobial peptides and their mechanisms of action. Biochim Biophys Acta, 1999;1462:11-28.
24. Matzukaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachiplesins as archetypes. Biochim Biophys Acta, 1999;1462:1-10.
25. Devine DA et al. Cationic peptides: distribution and mechanisms of resistance. Curr Pharm Des, 2002;8:703-714.
26. Bergman A et al. Accerelation of wound healing by topical application of honey. An animal model. The Am J of Surg, 1983;145:374-376.
27. Van den Berg AJ et al. An in vitro examination of the anti-oxidant and anti-infiammatoy properties of buckwheat honey. J of Wound Care, 2008;17:172-174.
28. Bashkaran K et al. Anti-inflammatory and antioxidant effect of tualang honey in alkali injury on the eyes of rabbits: experimental animal study. BMC Comple and alternative Med, 2011; 11:90.
29. Aljadi AM et al. Evaluation of the phenolic contents and antioxidant capacites of two malaysan floral honeys. Food Chem, 2004;85:513-518.
30. Tonks AJ et al. Honey stimulates inflammatory cytokine production from monocytes. Cytokine, 2003;21(5):242-247.
31. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns, 1998;24:157-161.
32. Subrahmanyam M. Topical application of honey in treatment of burns. Br J of Surg, 1991; 78:497-498.
33. Gethin G et al. Manuka honey vs hydrogel- a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J of Clin Nurs, 2009;18:466-474.
34. Molan P et al. Honey: a biologic wound dressing. Wound, 2015;27:141-151.
35. Pasupuleti VR et al. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev, 2017; 2017:11259510 Epub 2017 Jul 26.
36. Weissenstein A et al. Medical honey and its role in paediatric patients. Br J Nurs, 2014;23 (6):S30,S32-34.
37. Postrnes T et al. The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. Experientia, 1995; 51(9-10):986-989 (experientia 1995; J Pharm 1996).
2. Majino G. Man and wound in the ancient world. Cambridge: Harvard University Press, 1975
3. Jones R. Honey and healing through the ages. Honey and Healing. Cardiff: s.n., 2001, p.1-4
4. Nathan C . Antibiotics at the crossroads. Nature, 2004; 431, 899-902.
5. Visweswara RP et al. Honey, propolis and Royal Jelly: a comprehensive review of their biological actions and health benefits. Hindawi ,2017.
6. Kwakmann PHS et al: Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogenes. Eur J Clin Microbiol Infect Dis, 2011;30:251-257.
7. Leher RI et al: Interaction of human defensins with E. coli: mechanism of bacterial activity. J of Clin Investigation,1989;84:553-561.
8. Kwakmann PHS et al: Medical–grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Cl Infectious Diseases, 2008;46:1677-1683.
9. Molan PC et al: The evidence supporting the use of honey as a wound dressing. The intern J of Lower Extremity Wounds, 2005;5:353-356.
10. Simon A et al: Medical honey for wound care-still the "latest resort"?, Evidence-based Complementary and alternative medicine. 2009;6:165-173.
11. Molan PC. Clinical usage of honey as a wound dressing. The intern J of Lower Extremity Wounds, 2004;13:353-356.
12. Molan PC. The antibacterial activity of honey. Bee World, 1992;73:5-28.
13. Aureli P et al. Infant botulism and honey in Europe: a commentary. The pediatric infectious disease J, 2002;21:5-28.
14. Schneider LS et al. Influence of pH on wound healing: a new prospective for wound-therapy? Arch of Dermatol Res, 2007;298:413-420.
15. Adams C et al. Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (leptospermum scoparium) honey. Carbohydrate Res, 2008;343:651-659.
16. Mavric E et al. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptosperum scoparium) honeys from New Zealand. Molecular Nutrition and Food Res, 2008;52:483-489.
17. Fujivara S et al. A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin. The J of Biol Chem, 1990;265:11333-11337.
18. Lensky Y et al. Separate protein body compartments of the worker honeybee (Apis mellifera L.). Comparative Biochemistry and Physiology, 1983;75:607-615.
19. Knecht D et al. Patterns of larvel food-production by hypopharyngeal glands in adult worker honey-bees. Apidologie, 1990;21:457-468.
20. Al-Waili NS et al: Honey and microbial infection: a review supporting the use of honey for microbial control. J of Med food, 2011;14:1079-1096.
21. Majtan J. Methylglyoxal-a potential risk factor of manuka honey in healing of diabetic ulcers. Evid Based Complement Alternat Med, 2011; 2011:295494, Epub 2010 Oct 14.
22. Huang HV et al. Action of antimicrobial peptides: two-state model. Biochemistry, 2000;39:8347-8352.
23. Epand RM et al. Diversity of antimicrobial peptides and their mechanisms of action. Biochim Biophys Acta, 1999;1462:11-28.
24. Matzukaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachiplesins as archetypes. Biochim Biophys Acta, 1999;1462:1-10.
25. Devine DA et al. Cationic peptides: distribution and mechanisms of resistance. Curr Pharm Des, 2002;8:703-714.
26. Bergman A et al. Accerelation of wound healing by topical application of honey. An animal model. The Am J of Surg, 1983;145:374-376.
27. Van den Berg AJ et al. An in vitro examination of the anti-oxidant and anti-infiammatoy properties of buckwheat honey. J of Wound Care, 2008;17:172-174.
28. Bashkaran K et al. Anti-inflammatory and antioxidant effect of tualang honey in alkali injury on the eyes of rabbits: experimental animal study. BMC Comple and alternative Med, 2011; 11:90.
29. Aljadi AM et al. Evaluation of the phenolic contents and antioxidant capacites of two malaysan floral honeys. Food Chem, 2004;85:513-518.
30. Tonks AJ et al. Honey stimulates inflammatory cytokine production from monocytes. Cytokine, 2003;21(5):242-247.
31. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns, 1998;24:157-161.
32. Subrahmanyam M. Topical application of honey in treatment of burns. Br J of Surg, 1991; 78:497-498.
33. Gethin G et al. Manuka honey vs hydrogel- a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J of Clin Nurs, 2009;18:466-474.
34. Molan P et al. Honey: a biologic wound dressing. Wound, 2015;27:141-151.
35. Pasupuleti VR et al. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev, 2017; 2017:11259510 Epub 2017 Jul 26.
36. Weissenstein A et al. Medical honey and its role in paediatric patients. Br J Nurs, 2014;23 (6):S30,S32-34.
37. Postrnes T et al. The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. Experientia, 1995; 51(9-10):986-989 (experientia 1995; J Pharm 1996).
Come citare
Pierangeli, M., Ruocco, G., Recchi, V., Cecconato, V., Binci, C., Zavalloni, Y., … Scalise, A. (2020). Il miele medicale nella pratica clinica: la nostra esperienza in 75 casi trattati. Italian Journal of Wound Care, 4(1). https://doi.org/10.4081/ijwc.2020.58
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Articoli simili
- Riccardo Garcea, Paolo Savelli, Ulcera terminale di Kennedy e lesione da pressione: due differenti profili di responsabilità professionale per una lesione uguale , Italian Journal of Wound Care: V. 7 N. 2 (2023)
- Angela Peghetti, Diletta Olivari, Silvia Tedesco, Andrea Bellingeri, Marino Ciliberti, Antonio Di Lonardo, Corrado M. Durante, Antonino Grasso, Elia Ricci, Alessandro Scalise, Giovanni Pomponio, Prontosan®soluzione e Prontosan®Debridement Pad nel trattamento di diversi tipi di ferite cutanee: dichiarazioni basate su opinioni di esperti, serie di casi e revisione della letteratura/Prontosan®solution and Prontosan®Debridement Pad in the treatment of different types of cutaneous wounds: expert-based statements, case series and review of the literature , Italian Journal of Wound Care: V. 3 N. 2 (2019)
- Katia Feliziani, Arianna Dichiara, Giovanna Faccenda, Marco Romanelli, Battistino Paggi, Empowerment e cura centrata sulla persona: un progetto d'educazione terapeutica dedicato al paziente affetto da ulcere venose. Studio p , Italian Journal of Wound Care: V. 5 N. 1 (2021)
- Margherita Farì, Maurizio Mercuri , Alessandro Scalise , La continuità assistenziale nella gestione delle lesioni da pressione: un opuscolo informativo per la collaborazione ospedale-territorio , Italian Journal of Wound Care: V. 5 N. 1 (2021)
- Francesco Petrella, Giuseppe Nebbioso, Marcello Aquino, Mario Bellisi, Sara Carella, Rosaria Grace Catalfamo, Diletta Donateo, Pasquale Esposito, Pierluigi Gallo, Maria Grazia Mezzasalma, Stefano Riccardi, Concetta Romano, Alessandro Scanguzzi, Studio osservazionale sull’utilizzo di un prodotto in garza contenente Rigenase® e poliesanide nel trattamento della cute perilesionale e delle ulcere venose (<6cm2) , Italian Journal of Wound Care: V. 6 N. 2 (2022)
- Matteo Bucalossi, Fabrizio Mariani, Mononucleate da sangue periferico autologhe da filtrazione selettiva per il trattamento delle lesioni croniche dell'arto inferiore: Risultati a 4 anni , Italian Journal of Wound Care: V. 5 N. 2 (2021)
- Elsa Vitale, Lucia Rosa De Angelis, Francesco Germini, Le tecniche e le soluzioni utilizzate nella detersione delle ulcere: una revisione della letteratura , Italian Journal of Wound Care: V. 4 N. 1 (2020)
- Stefano Mancin, Elena Alterchi, Silvia Finazzi, Salvatore Badalamenti, Assistenza infermieristica e wound care nel paziente affetto da insufficienza renale cronica in trattamento dialitico , Italian Journal of Wound Care: V. 5 N. 1 (2021)
- Elia Ricci, Monica Pittarello, Francesco Giacinto, Studio di valutazione del presidio Rigenoma con ozoile nel trattamento di lesioni cutanee croniche , Italian Journal of Wound Care: V. 6 N. 2 (2022)
- Giuseppe Nebbioso, Viviana Nebbioso, Carmela Orefice, Francesco Petrella, Ciro Falasconi, Health literacy, empowerment e comunicazione nel wound care/Health literacy, empowerment and communication in wound care management , Italian Journal of Wound Care: V. 2 N. 2 (2018)
Puoi anche Iniziare una ricerca avanzata di similarità per questo articolo.