https://doi.org/10.4081/ijwc.2024.113
Peripheral blood mononuclear cells enhance sacral wound healing in a patient with spinal cord injury: a case report
Submitted: April 16, 2024
Accepted: November 26, 2024
Published: January 24, 2025
Accepted: November 26, 2024
Abstract Views: 315
PDF: 131
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Pressure ulcers are one of the biggest problems in people with Spinal Cord Injury (SCI); this could affect both acute patients and people with chronic SCI, and in the same way bed-ridden patients and people with greater autonomy due to friction and shear mechanisms they are subjected during wheelchair bed transfers. The occurrence of a pressure injury also limits the rehabilitation potential and functional self-recovery. In this case, we reported the story of a 50-year-old man with paraplegia who developed a sacral pressure ulcer in the first days after SCI. Despite the many types of advanced dressings used, the efforts made, the care in positioning, we were unable to close the wound for 5 months. According to plastic surgeons, we decided to use autologous Peripheral Blood Mononuclear Cells (PBMNC) injections to accelerate the process of healing and in a few weeks it led to the complete closure of the sacral wound. PBMNC could be an interesting tool to reduce closing times in addition to advanced dressing; it could be used both in patients during the first period of rehabilitation after SCI and in out-patient settings.
1. Li Z, Lin F, Thalib L, Chaboyer W. Global prevalence and incidence of pressure injuries in hospitalised adult patients: A systematic review and meta-analysis. Int J Nurs Stud 2020;105.
DOI: https://doi.org/10.1016/j.ijnurstu.2020.103546
2. Hajhosseini B, Longaker MT, Gurtner GC. Pressure Injury. Ann Surg 2020;271:671–9.
DOI: https://doi.org/10.1097/SLA.0000000000003567
3. Toita R, Shimizu E, Murata M, Kang JH. Protective and healing effects of apoptotic mimic-induced M2-like macrophage polarization on pressure ulcers in young and middle-aged mice. J Controlled Release 2021;330:705–14.
DOI: https://doi.org/10.1016/j.jconrel.2020.12.052
4. Gurevich DB, Severn CE, Twomey C, et al. Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. EMBO J 2018;37:e97786.
DOI: https://doi.org/10.15252/embj.201797786
5. Martin P, Gurevich DB. Macrophage regulation of angiogenesis in health and disease. Semin Cell Dev Biol 2021;119:101–10.
DOI: https://doi.org/10.1016/j.semcdb.2021.06.010
6. Rehak L, Giurato L, Meloni M, et al. The immune-centric revolution in the diabetic foot : monocytes and lymphocytes role in wound healing and tissue regeneration — a narrative review. J Clin Med 2022;11:889.
DOI: https://doi.org/10.3390/jcm11030889
7. Di Pardo A, Cappello E, Pepe G, et al. Infusion of autologous-peripheral blood mononuclear cells : a new approach for limb salvage in patients with diabetes. In: 7th International Diabetic Foot Congress abu Dhabi. IFD Congress Abu Dhabi 4-8 December 2017; 2017. p. International Diabetic Foot Congress Abu Dhabi 4-8.
8. Proto JD, Doran AC, Gusarova G, et al. Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 2018;49:666-77.e6.
DOI: https://doi.org/10.1016/j.immuni.2018.07.015
9. Nosbaum A, Prevel N, Truong HA, et al. Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. J Immunol 2016;196:2010–4.
DOI: https://doi.org/10.4049/jimmunol.1502139
10. Li J, Tan J, Martino MM, Lui KO. Regulatory T-cells: Potential regulator of tissue repair and regeneration. Front Immunol 2018;9:585.
DOI: https://doi.org/10.3389/fimmu.2018.00585
11. Danon D, Kowatch MA, Roth GS. Promotion of wound repair in old mice by local injection of macrophages. Proc Natl Acad Sci USA 1989;86:2018-20.
DOI: https://doi.org/10.1073/pnas.86.6.2018
12. Zuloff-Shani A, Kachel E, Frenkel O, et al. Macrophage suspensions prepared from a blood unit for treatment of refractory human ulcers. Transfus Apher Sci 2004;30:163–7.
DOI: https://doi.org/10.1016/j.transci.2003.11.007
13. Zuloff-Shani A, Adunsky A, Even-Zahav A, et al. Hard to heal pressure ulcers (stage III-IV): Efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial. Arch Gerontol Geriatr 2010;51:268–72.
DOI: https://doi.org/10.1016/j.archger.2009.11.015
14. Rigato M, Monami M, Fadini GP. Autologous cell therapy for peripheral arterial disease: systematic review and meta-analysis of randomized, nonrandomized, and noncontrolled studies. Vol. 120, Circulation Research. Lippincott Williams and Wilkins; 2017. p. 1326–40.
DOI: https://doi.org/10.1161/CIRCRESAHA.116.309045
15. Spaltro G, Straino S, Gambini E, et al. Characterization of the Pall Celeris system as a point-of-care device for therapeutic angiogenesis. Cytotherapy 2015;17:1302–13.
DOI: https://doi.org/10.1016/j.jcyt.2015.04.006
How to Cite
delli Santi, G., Pilati, C., Borgognone, A., & Tiberti, S. (2025). Peripheral blood mononuclear cells enhance sacral wound healing in a patient with spinal cord injury: a case report. Italian Journal of Wound Care, 8(3). https://doi.org/10.4081/ijwc.2024.113
Copyright (c) 2025 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Aurora Parodi, Valeria Maria Messina, Manuela Martolini, Shpresa Haxhiaj, Emanuele Claudio Cozzani, Update on the management and treatment of patients with chronic skin lesions , Italian Journal of Wound Care: Vol. 5 No. 2 (2021)
- Roberto Polignano, Roberta Gatto, Irene Ruffino, Alessandra Pavanelli, Francesca Falciani, Topical application of cannabinoid-based galenic preparations for pain treatment in chronic leg ulcer: case reports , Italian Journal of Wound Care: Vol. 7 No. 1 (2023)
- Michela Crisci, Giovanni Lepore, Federica Feleppa, Alessandro Crisci, Fabiana Flagiello, Cytomorphological analysis of liquid platelet-rich fibrin produced with the DUO fixed angle centrifuge (Process, France) for use in the regenerative therapy of skin ulcers , Italian Journal of Wound Care: Vol. 7 No. 3 (2023)
- Francesco Petrella, Giuseppe Nebbioso, Marcello Aquino, Mario Bellisi, Sara Carella, Rosaria Grace Catalfamo, Diletta Donateo, Pasquale Esposito, Pierluigi Gallo, Maria Grazia Mezzasalma, Stefano Riccardi, Concetta Romano, Alessandro Scanguzzi, Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin , Italian Journal of Wound Care: Vol. 6 No. 2 (2022)
- Giuseppe Nebbioso, Ciro Falasconi, Viviana Nebbioso, Francesco Petrella, Antiseptics and control of bacterial load in venous ulcers , Italian Journal of Wound Care: Vol. 2 No. 2 (2018)
- Andrea Pazzini, Barbara Biselli, Chiara Vannini, Elisabetta Fabbri, Felice Falabella, Maria Giulia Santandrea, Marianna Marziliano, Nicole Gagliardi, Sara Di Giandomenico, Simona Scotto di Minico, Vito Di Biasi, Can the Braden scale predict the development of pressure injuries in intensive care? , Italian Journal of Wound Care: Vol. 7 No. 3 (2023)
- Katia Feliziani, Arianna Dichiara, Giovanna Faccenda, Marco Romanelli, Battistino Paggi, Empowerment and patient-centered care: A therapeutic educational project for patient with venous ulcers. A pilot study , Italian Journal of Wound Care: Vol. 5 No. 1 (2021)
- Federica Buzzi, Hevan Adel Al-Atroushy, Nizar Bakir Yahya, Hozan Dilneya Rwanduzi, Stefano Maindi, Is it possible to use a 100% Medical Grade Honey in the premature babies? , Italian Journal of Wound Care: Vol. 5 No. 2 (2021)
- Alberto Garavello, Orazio Caudullo, Paola Fiamma, Enrico Oliva, Ginevra Oliva, Relational and psychological problems in venous ulcer therapy: questions and answers , Italian Journal of Wound Care: Vol. 8 No. 1 (2024)
- Angela Peghetti, Diletta Olivari, Silvia Tedesco, Andrea Bellingeri, Marino Ciliberti, Antonio Di Lonardo, Corrado M. Durante, Antonino Grasso, Elia Ricci, Alessandro Scalise, Giovanni Pomponio, Prontosan®solution and Prontosan®Debridement Pad in the treatment of different types of cutaneous wounds: expert-based statements, case series and review of the literature , Italian Journal of Wound Care: Vol. 3 No. 2 (2019)
You may also start an advanced similarity search for this article.